Autophagy has been linked to longevity in many species, but the underlying mechanisms are unclear.Using a GFP-tagged and a new tandem-tagged Atg8/LGG-1 reporter, we quantified autophagic vesicles and performed condor leg holster autophagic flux assays in multiple tissues of wild-type Caenorhabditis elegans and long-lived daf-2/insulin/IGF-1 and glp
Migrating eastern North American monarch butterflies use a time-compensated sun compass to adjust their flight to the southwest direction.Although the antennal genetic circadian clock and the azimuth of the sun are instrumental for proper function of the compass, it is unclear how these signals are represented on a neuronal level and how they are i
With critical limb ischemia (CLI) being a multi-factorial disease, it is becoming evident that gene therapy with a multiple bio-functional growth factor could achieve better therapeutic outcomes.Cytochrome P450 epoxygenase-2J2 (CYP2J2) and its catalytic products epoxyeicosatrienoic acids (EETs) exhibit pleiotropic biological activities, including p
This article presents an integrative model milwaukee mnm1-600 for the endorsement of pseudoscience: the explanation-polarisation model.It is based on a combination of perceived explanatory satisfaction and group polarisation, offering a perspective different from the classical confusion-based conception, in which pseudoscientific beliefs would be a